The C-terminal amino acid sequence of growth hormones from human, monkey, whale, and sheep pituitary glands.

In another communication we have reported partial Nterminal amino acid sequences for growth hormones (somatotropins) of several species (1) ; these studies have indicated that whale, monkey, and human growth hormones are singlechain polypeptides at their N-terminus. To seek further evidence that these proteins are made up of single polypeptide chains, as well as to make additional comparisons with beef and sheep growth hormones, investigations at the C-terminus of these proteins have been carried out by enzymic and chemical means. Results of these investigations are reported herein.